Alnylam Pharmaceuticals, Inc., a biopharmaceutical company, focuses on discovering, developing, and commercializing novel therapeutics based on ribonucleic acid interference. The company's pipeline of investigational RNAi therapeutics focuses on genetic medicines, cardio-metabolic diseases, hepatic infectious diseases, and central nervous system (CNS)/ocular diseases. Its marketed products include ONPATTRO (patisiran), a lipid complex injection for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults; GIVLAARI for the treatment of adults with acute hepatic porphyria (AHP); and OXLUMO (lumasiran) for the treatment of primary hyperoxaluria type 1 (PH1). In addition, the company is developing givosiran for the treatment of adolescent patients with AHP; patisiran for the treatment of transthyretin amyloidosis, or ATTR amyloidosis, with cardiomyopathy; cemdisiran to treat complement-mediated diseases; ALN-AAT02 for the treatment of AAT deficiency-associated liver disease; ALN-HBV02 to treat chronic HBV infection; Zilebesiran to treat hypertension; and ALN-HSD to treat NASH. Further, it offers Fitusiran for the treatment of hemophilia and rare bleeding disorders, Inclisiran to treat hypercholesterolemia, lumasiran for the treatment of advanced PH1 and recurrent renal stones, and vutrisiran for the treatment of ATTR amyloidosis, which is in phase 3 clinical trial. Alnylam Pharmaceuticals, Inc. has strategic collaborations with Regeneron Pharmaceuticals, Inc. to discover, develop, and commercialize RNAi therapeutics for a range of diseases by addressing therapeutic targets expressed in the eye and CNS; and Sanofi Genzyme to discover, develop, and commercialize RNAi therapeutics. It also has license and collaboration agreements with Novartis AG; Vir Biotechnology, Inc.; Dicerna Pharmaceuticals, Inc.; Ionis Pharmaceuticals, Inc.; and PeptiDream, Inc. The company was founded in 2002 and is headquartered in Cambridge, Massachusetts.

Alnylam Pharmaceuticals, Inc.

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Income Statement	Sep '25	Jun '25	Mar '25	Dec '24	Sep '24	Jun '24
Total Revenues	1,249	773.7	594.2	593.2	500.9	659.8
Total Revenues %Chg	149.3%	17.3%	20.2%	34.9%	-33.3%	107%
Net Product Revenues
Net Revenues from Collaborations
Royalty Revenue
Cost of Sales	200.2	143	71	102.8	85.9	68.7
Cost of Goods Sold
Cost of Collaborations and Royalties
Gross Profit	1,048.9	630.7	523.1	490.3	415	591.2
Gross Profit Margin	84%	81.5%	88%	82.7%	82.9%	89.6%
Selling, General & Administrative Expenses	322.1	323.3	239.9	295.3	221	248.4
Selling, General and Administrative
Research & Development Expenses	358.8	323.6	265.1	300.2	270.9	294.1
Research and Development
Operating Profit	368	-16.2	18.1	-105.2	-76.9	48.6
Income from Operations
Operating Margin	29.5%	-2.1%	3%	-17.7%	-15.4%	7.4%
Interest and Investment Income	28.7	27.5	28.7	31	32.1	29.2
Interest Income
Interest Expense	-44.4	-40.2	-38.6	-39	-34.4	-33.3
Interest Expense
Non-Operating Income	-242.3	-25.6	-109.4	-339.3	-61.3	-115.5
Change in Fair Value of Liability Obligation
Gain on Litigation Settlement
Other Expense, Net
Loss on the Extinguishment of Debt
Loss Related to Convertible Debt
Other (Expense) Income, Net
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Other (Expense) Income, Net
Total Non-Operating Income	-258	-38.3	-119.3	-347.2	-63.5	-119.6
Income Before Provision for Income Taxes	239	-35.4	-41.6	-194	-108.7	-11.2
Income Before Income Taxes
Provision for Income Taxes	12.1	-30.9	-15.9	110.2	-2.9	-5.7
Benefit from Income Taxes
Consolidated Net Income	226.9	-4.4	-25.7	-304.2	-105.8	-5.4
Net Income Attributable to Common Shareholders	251.1	-66.3	-57.5	-167.5	-111.6	-16.9
Net Loss
Net Income
Basic EPS	1.9	-0.5	-0.4	-0.7	-0.9	-0.1
Diluted EPS	1.8	-0.5	-0.4	-0.7	-0.9	-0.1
Basic Weighted Average Shares Outstanding	131.4	130.6	129.7	129.1	128.6	126.7
Total Shares Outstanding	131.8	131	130.3	129.3	128.8	128
Diluted Weighted Average Shares Outstanding	137.3	130.6	129.7	129.1	128.6	126.7
EBITDA	381.8	-2.3	32.5	-91	-62.9	63.6
Effective Tax Rate	5.1%	87.4%	38.2%	-56.8%	2.7%	51.2%