Amortization of Right-of-Use Operating Lease Assets
Operating Activities > Adjustments to Reconcile Net Income to Net Cash Provided by Operating Activities > Amortization of Patents
Operating Activities > Adjustments to Reconcile Net Income to Net Cash Provided by Operating Activities > Amortization of Licenses
Amortization of Other Assets
Share-Based Compensation Expense
31.1
29.7
29.7
36.1
32
30.7
Stock-Based Compensation Expense
Other Adjustments
-33.1
21.1
2.2
8.2
0.2
4.1
Amortization of Discount on Investments, Net
Amortization of Debt Issuance Costs
Operating Activities > Adjustments to Reconcile Net Income to Net Cash Provided by Operating Activities > Amortization of 2¾ Percent Convertible Senior Notes Discount
Amortization of 1 Percent Convertible Senior Notes Discount
Operating Activities > Adjustments to Reconcile Net Income to Net Cash Provided by Operating Activities > Amortization of Convertible Senior Notes Discount
Operating Activities > Adjustments to Reconcile Net Income to Net Cash Provided by Operating Activities > Amortization of Long-Term Financing Liability for Leased Facility
Non-Cash Royalty Revenue Related to Sale of Royalties
Non-Cash Interest Related to Sale of Future Royalties
Gain on Investment in Regulus Therapeutics Inc.
Loss on Early Retirement of Debt
Gain (Loss) on Early Retirement of Debt
Non-Cash Losses Related to Patents, Licensing, Property, Plant and Equipment and Strategic Investments
Tax Benefit from Other Unrealized Gains on Securities
Non-Cash Losses Related to Patents
Gain (Loss) on Sale of Real Estate Assets
Gain on Investments, Net
Deferred Income Taxes, Including Changes in Valuation Allowance
Non-Cash Losses Related to Other Assets
Non-Cash Gains Related to Other Assets
Changes in Trade Receivables
28
-12.9
52.5
-74.3
9.3
-22.1
Contracts Receivable
Changes in Inventories
-2.1
-13.5
1
-5
0.3
-0.8
Inventories
Changes in Accounts Payable
-8.8
5.7
-26
35.2
-2.2
-3.2
Accounts Payable
Changes in Accrued Expenses
94.6
23.2
-42.7
14.7
16.1
17.2
Accrued Compensation
Accrued Liabilities and Other Liabilities
Accrued Liabilities
Changes in Income Taxes Payable
0
-0
0.1
-0
-0.2
-1.9
Income Taxes
Changes in Unearned Revenue
-16.1
-20.8
-13.7
-14.3
-33
-62.7
Deferred Contract Revenue
Changes in Other Operating Activities
-101
-10.2
-12.4
-17.7
1.2
-20.4
Other Current and Long-Term Assets
Long-Term Income Tax Receivable
Long-Term Income Taxes Receivable
Cash from Operating Activities
-131.4
151.3
-150.8
-116.1
-115
-119.9
Net Cash Provided by Operating Activities
Investing Activities
Sep '25
Jun '25
Mar '25
Dec '24
Sep '24
Jun '24
Mar '24
Dec '23
Sep '23
Jun '23
Mar '23
Dec '22
Capital Expenditure
-5.3
-12.3
-12.6
-25.5
-9.1
-6.2
Purchases of Property, Plant and Equipment
Proceeds from Sale of Property, Plant & Equipment
—
—
—
—
—
—
Proceeds from Sale of Real Estate Assets
Purchases of Intangible Assets
-1.7
-2
-0.7
-2.5
12.8
-14
Acquisition of Licenses and Other Assets, Net
Purchases of Investments
-323.9
-491.6
-311.1
-333.6
-715.4
-284.9
Purchases of Short-Term Investments
Purchases of Strategic Investments
Proceeds from Sale of Investments
422.2
385.8
494.8
429.9
370.9
367.6
Proceeds from Sale of Short-Term Investments
Proceeds from the Sale of Equity Investments
Proceeds from the Sale of Regulus Therapeutics, Inc.
Proceeds from the Sale of Strategic Investments
Cash from Investing Activities
91.3
-120.1
170.5
68.2
-340.8
62.5
Net Cash Provided by Investing Activities
Financing Activities
Sep '25
Jun '25
Mar '25
Dec '24
Sep '24
Jun '24
Mar '24
Dec '23
Sep '23
Jun '23
Mar '23
Dec '22
Issuance of Short-Term Debt
—
—
—
—
—
—
Proceeds from Borrowing on Line of Credit Facility
Net Issuance / (Repayments) of Short-Term Debt
—
—
—
—
—
—
Issuance of Long-Term Debt
—
—
—
—
—
—
Proceeds from Building Mortgage Debt, Net of Issuance Costs
Proceeds from Issuance of 1.75 Percent Convertible Senior Notes
Proceeds from the Issuance of 0 Percent Convertible Senior Notes
Proceeds from the Issuance of 0.125 Percent Convertible Senior Notes
Repayments of Long-Term Debt
-0
-0
-0
-44.4
-22.3
-0
Principal Payments on Debt and Capital Lease Obligations
Repurchase of 1 Percent Convertible Senior Notes
Repayment of Remaining Principal Amount of 1 Percent Convertible Senior Notes at Maturity
Principal Payments on Mortgage Debt
Net Issuance / (Repayments) of Long-Term Debt
-0
-0
-0
-44.4
-22.3
-0
Issuance of Common Shares
81.3
1.3
2.2
0.4
496.1
2.6
Proceeds from Issuance of Common Stock Through Equity Plans, Net
Proceeds from Issuance of Common Stock in Public Offering, Net
Proceeds from the Issuance of Common Stock to Biogen
Proceeds from the Issuance of Common Stock to Novartis
Repurchases of Common Shares
—
—
—
-0.2
-0.1
—
Repurchases and Retirements of Common Stock
Payments of Tax Withholdings Related to Vesting of Employee Stock Awards and Exercise of Employee Stock Options
Net Issuance / (Repurchases) of Common Shares
81.3
1.3
2.2
0.3
496
2.6
Other Financing Activities
—
—
—
—
—
—
Proceeds from Issuance of Common Stock in Akcea Therapeutics, Inc. from Its Initial Public Offering, Net of Underwriters' Discount
Proceeds from the Sale of Akcea Therapeutics, Inc. Common Stock to Novartis in a Private Placement
Offering Costs Paid
Payment to Settle Financing Liability for Leased Facility
Excess Tax Benefits from Stock-Based Compensation Awards
Proceeds from Sale of Future Royalties
Payments of Transaction Costs Related to Sale of Future Royalties
